RESEARCH

In Sulzer Lab we conduct research on the synaptic basis of normal learning and behavior and how these synapses are involved in nervous system disorders, including neurodegeneration such as Parkinson’s and Huntington’s disease, neurodevelopmental diseases including autism and schizophrenia, and behavior disorders such as drug addiction, depression and post-traumatic stress.

Publications

Cataldi S, Lacefield C, Shashaank N, Sulzer D. Direct Pathway Neurons in the Mouse Ventral Striatum Are Active During Goal-Directed Action but Not Reward Consumption During Operant Conditioning. Biomedicines. 2024 Dec 2;12(12). doi: 10.3390/biomedicines12122755. PubMed PMID: 39767662; PubMed Central PMCID: PMC11673053.select
Cataldi S, Lacefield C, Shashaank N, Kumar G, Boumhaouad S, Sulzer D. Decreased Dorsomedial Striatum Direct Pathway Neuronal Activity Is Required for Learned Motor Coordination. eNeuro. 2022 Sep-Oct;9(5). doi: 10.1523/ENEURO.0169-22.2022. Print 2022 Sep-Oct. PubMed PMID: 36171055; PubMed Central PMCID: PMC9557335.select
Cataldi S, Stanley AT, Miniaci MC, Sulzer D. Interpreting the role of the striatum during multiple phases of motor learning. FEBS J. 2022 Apr;289(8):2263-2281. doi: 10.1111/febs.15908. Epub 2021 May 24. Review. PubMed PMID: 33977645; PubMed Central PMCID: PMC8590810.select
Somayaji M, Cataldi S, Choi SJ, Edwards RH, Mosharov EV, Sulzer D. A dual role for α-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32701-32710. doi: 10.1073/pnas.2013652117. Epub 2020 Dec 3. PubMed PMID: 33273122; PubMed Central PMCID: PMC7768743.select
Cataldi S, Follett J, Fox JD, Tatarnikov I, Kadgien C, Gustavsson EK, Khinda J, Milnerwood AJ, Farrer MJ. Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice. NPJ Parkinsons Dis. 2018;4:27. doi: 10.1038/s41531-018-0063-3. eCollection 2018. PubMed PMID: 30155515; PubMed Central PMCID: PMC6104078.select
Volta M, Beccano-Kelly DA, Paschall SA, Cataldi S, MacIsaac SE, Kuhlmann N, Kadgien CA, Tatarnikov I, Fox J, Khinda J, Mitchell E, Bergeron S, Melrose H, Farrer MJ, Milnerwood AJ. Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice. Elife. 2017 Sep 20;6. doi: 10.7554/eLife.28377. PubMed PMID: 28930069; PubMed Central PMCID: PMC5633343.select
Volta M, Cataldi S, Beccano-Kelly D, Munsie L, Tatarnikov I, Chou P, Bergeron S, Mitchell E, Lim R, Khinda J, Lloret A, Bennett CF, Paradiso C, Morari M, Farrer MJ, Milnerwood AJ. Chro n ic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release. Parkinsonism Relat Disord. 2015 Oct;21(10):1156-63. doi: 10.1016/j.parkreldis.2015.07.025. Epub 2015 Aug 1. PubMed PMID: 26282470.select
Walker MD, Volta M, Cataldi S, Dinelle K, Beccano-Kelly D, Munsie L, Kornelsen R, Mah C, Chou P, Co K, Khinda J, Mroczek M, Bergeron S, Yu K, Cao LP, Funk N, Ott T, Galter D, Riess O, Biskup S, Milnerwood AJ, Stoessl AJ, Farrer MJ, Sossi V. Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging. J Parkinsons Dis. 2014;4(3):483-98. doi: 10.3233/JPD-140344. PubMed PMID: 25000966.
Complete list of published work in My Bibliography